Buddhashrijnana was born in Taxila by the River Indus. He was ordained in the great monastic academy of Nalanda. He became a scholar monk renowned in the Perfection of Wisdom (Prajnaparamita) tradition. Later, he went to Uddiyana and received many secret tantras from the Acharya Lilavajra and a yogini named Guneru, and by practising their instruction he attained deep concentration. Then in the north of Uddiyana he found a low caste consort called Jatijala with whom he lived for six months and through the blessing of Jambhala, the God of Wealth, he perfected the yoga of bliss. In Jalandhara to the east of Uddiyana he received the wisdom tantras from Balipada, who was an emanation of the great master Jalandharipa. In the south of India, in Kongkana he met the Acharya Patalipada with his eighteen yogis and yoginis and from him Buddhashrijnana received the Guhyasamaja-tantra. He practiced the Guhyasamaja-tantra in Kuva grove behind Bodhgaya and there he received a visionary injunction to approach the Bodhisattva Manjushri for ultimate realization. He set out for Manjushri's abode at Wutaishan in China.
Buddhashrijnana walked for only half a day when he encountered an old monk with his robe piled on his head ploughing a field with a low caste woman. Hiding his disgust he begged for food and the old monk gave him a fish that his dog had vomitted up. Buddhashrijnana, hiding his disgust, rejected it and the woman kindly cooked him some fresh rice and invited him to stay the night. By the time the old monk returned, quite drunk, in the evening, Buddhashrijnana had intuited that he was a tantric master and asked him for instruction. The old monk inscribed a mandala and the nineteen Manjuvajra deities, amongst whom were the monk, his woman and their dog, appeared, shining radiantly. Under the old monk's tutelage Buddhashrijnana, through the Mind Series preceptsd the nature of mind. Due, however, to the lack of faith he showed in rejecting the fish he was offered, he did not attain rainbow body, but achieved the level of Vajradhara in the bardo after his death. Some say the old monk was Manjushri's emanation, Manjushrimitra.